M.E. Nikolaev Republic Hospital №1 – National Center of Medicine is a multisectoral, specialized hospital complex, which provides specialized and high-tech medical care for the population of the Republic of Sakha (Yakutia)
“National Center of Medicine” consists of 5 Health-Diagnostic Centers (Consulting-Diagnostic, Clinical, Pediatric, Perinatal and Republic Cardiologic Centers) with 36 clinical specialized departments, which have 862 beds, 7 reanimation departments, 24 operating rooms and a 11 polyclinic departments with a capacity of 905 visits per shift.
Every year, in “National Center of Medicine”, more than 28,000 patients receive in-patient care, about 30,000 patients attend out-clinic departments, more than 2,000,000 researches, 12,000 operations and 3,000 child deliveries are conducted.
The activity of “National Center of Medicine” highly influences on the health indicators of the entire population on the Republic, such as death and birth rate; maternal, infant and perinatal mortality rates, circulatory system morbidity, etc.
“National Center of Medicine” is a clinical base for the students of Medical Institute of NEFU and Yakut Medical Base Community College.
Every year “National Center of Medicine”, as the largest multisectoral medical organization in the Republic of Sakha (Yakutia), actively promotes high-tech treatment methods for the patients. At present, the high-tech treatment is being provided in 18 medical disciplines. In total between 2007 to 2022 the high-tech treatment (HTT) was provided to 11,391 patients, including 5,035 were paid by the program of Compulsory Medical Insurance (CMI) and 6,356 – were provided with HTT, which is not included in Basic Program of CMI.
On April 30, 2022, the Cardiovascular Center began its work, implemented as part of the activities of the Social Development Plan for Economic Growth Centers of the Republic of Sakha (Yakutia) under the federal program «Far East and Transbaikalia».
The main task of the Cardiovascular Center is to provide affordable high-tech cardiac medical care to the population of the Republic in order to reduce complications and mortality from diseases of the circulatory system.
Since the opening of the Cardiovascular Center, more than 4,000 patients have been treated, about 400 heart surgeries and more than a thousand endovascular surgeries on vessels, including those in emergency cases, have been performed. For the first time, cardiologists have performed 5 unique arterial stenting operations using intravascular ultrasound, which allows patients to minimize risks. Thus, heart surgeries were performed: coronary artery bypass grafting — 136 (100 in 2022), incl. in conditions of cardiopulmonary bypass — 95 (83 in 2022); heart defects and formations — 36 (30 in 2022); pacemaker implantations — 251 (190 in 2022); stenting and angioplasty of coronary arteries — 1083 (698 in 2022); ablations for cardiac arrhythmias — 58 (50 in 2022); neurosurgical operations for cerebral strokes: clipping of aneurysms — 35 (14 in 2022); microspiral embolization of aneurysms — 7 (4 in 2022), thromboextraction — 6.
In 2018 the most important achievements in transplantology were an operation on heart transplant, multiorgan recovery of organs for donation with performing transplants of 2 kidneys, a liver and a heart.
In total between 2001 to 2022 the doctors performed 115 kidney transplants and 20 liver transplant, including 21 cadaveric kidneys and 5 – livers.
Every year in Surgery Departments №1, №2 and №3 of Clinical Center the doctors start to perform new and more difficult videoendoscopic operations in case of gastrointestinal tract organs’ severe diseases, including cancer. In 2019 – endoscopic wirsungotomy, wirsung duct stenting, real atypical torascopic resection of lung in case of echinococcosis, laparoscopic gastrectomy in case of malignant neoplasm of stomach. In 2020, for the first time, bariatric surgeries were performed on patients with morbid obesity using new digital technologies. Also, laparoscopic plastic of abdominal wall in case of post-operation hernia, and difficult reconstruction operations on benign tumors and liver echinococcosis, in case of esophagus stricture and severe diseases of large intestine.
In the Perinatal Center, the volume of completed cases of IVF according to compulsory medical insurance has increased to 280, efficiency of IVF reached 32%. We have implemented a new method of organ-preserving surgery for ectopic pregnancy and methods of controlled 2 balloon tamponade for obstetric bleeding, diagnostic methods for determining critical congenital heart defects, histological examination of the placenta for early diagnosis of congenital infections in newborns.
The Medical Genetic Center continues research and implementation of methods for diagnosing diseases associated with gene mutations, for example, in 2019, methods for molecular diagnostics of a severe neurodegenerative disease in young children — neuronal ceroid lipofuscinosis type 6, congenital lung diseases that cause emphysema due to a mutation in the Pi gene alpha-1 antitrypsin, tumor-like diseases of the skeleton — multiple exostotic chondrodysplasia, as well as methods for the simultaneous diagnosis of hereditary diseases using biochip technology.
Diagnostic studies have been introduced: whole body diffusion for cancer metastases search, MRI of the heart, placenta, fetus and mammary glands, MR enterography, low-dose CT scan — new protocols for reducing radiation exposure have been developed that allow reducing the radiation dose without compromising diagnostic information, panels have been expanded tumor markers, fetal echocardiography.
In addition, the modern development of gene technologies dictates the development of treatment methods using new cellular technologies, for example, in the Republic of Sakha (Yakutia), on the basis of National Center of Medicine, a technological platform will be created for obtaining an individual innovative vaccine based on dendritic cells and macrophages for the treatment of oncological diseases. It is planned to conduct clinical trials of clinical protocols for the immunotherapy of cancer patients with vaccine based on dendritic cells and macrophages, as well as testing of new medical technology, and registration of new high-tech methods of treatment.
To date, in order to develop personalized medicine, work is underway to create and expand biological banks. The Biobank will include a Bank of stem and reproductive cells, a DNA Bank of congenital, hereditary and multifactorial pathology of people of Yakutia. The use of cells and tissues in oncology, hematology, cardiology, reproductive medicine and other areas of medicine will improve the efficiency of patient treatment.
In order to reduce the one-year mortality of patients with malignant neoplasms, to reduce the hospital mortality of children with oncological diseases, we plan to introduce autologous bone marrow transplantation as a stage of the high-dose chemotherapy protocol, perform histological verification with immunohistochemistry of malignant neoplasms in pediatric oncology, and improve immunohistochemical studies in oncohematology.
In Pediatric Center the surgery of newborn children is improving with success. Also the staff is changing the equipment for minimally-invasive endosurgical hardware. The mortality rate of newborn children with surgical pathology was reduced to 3,5%. The new methods of surgery were implemented, such as endosurgical sanitations of abdomen cavity in case of peritonitis, new plastic reconstructive operations in case of kidney development disorders, urethra – laparoscopic pyeloplastic, treatment of hypospadias, epispadias. Our Surgeons perform torascopic operations on babies and newborns – lobectomy in case of a lung disease, plastic of diaphragm defect — in case of congenital diaphragm hernias, torascopic esophagoanastomosis — esophageal atresia, proctoplastic – anus atresia, congenital agangliosis of large intestine.
Since 2017 the doctors perform operations on implanting cochlear implants for children with congenital deafness, at the moment more than 60 operations were completed.
The method of surgical treatment in the endovascular way for arrhythmias was implemented and has been used for several years now in Roentgenosurgical Diagnostics and Care Methods Department of Consulting-Diagnostic Center. Since 2014 the surgeons have performed more than 143 radiofrequency heart ablations, recently unique operations were performed with usage of the “treatment with cold” method (cryoablation), which bases on extreme freezing of myocardium areas, which are the source of arrhythmias formations. The innovative method helps to shorten operation time while keeping the same procedure safety, and also it is easier and more comfortable for the surgeon. Unlike radio frequency ablation, this method is safer and more painless. The doctors use this in case of different kinds of arrhythmia, due to which post-operational recovery goes much faster.
Also the operations on chemoembolization of liver-tumors feeding arteries were performed for the first time. The second year in a row the physicians of department learn new methods of treatment for the patients, suffering from chronic lower-limbs arteries diseases.
To confirm compliance with the quality and safety standards of the voluntary certification of the Federal Service for Supervision of Healthcare, the National Center of Medicine was the first in the Republic of Sakha (Yakutia) to receive the certificate “Quality and Safety of Medical Activities”.